| Alu中剪接位点的研究 |
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| 引用本文： | 刘波,罗辽复,张利绒,晋宏营.Alu中剪接位点的研究[J].生物信息学,2008,6(1):3-5,11. |
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| 作者姓名： | 刘波 罗辽复 张利绒 晋宏营 |
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| 作者单位： | 内蒙古大学理工学院,呼和浩特,010021 |
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| 摘 要： | 对Alu剪接位点双碱基的类型、分布进行了分析，发现非标准剪接（不满足GT-AG规则）占很大优势。而且非标准剪接的分布频率会随不同的染色体而变化，在Alu剪接较多的11、12、17号染色体上分布最多。通过对Alu及其剪接住点碱基关联的计算分析，说明在Alu中剪接位点双碱基的这种异常使用主要是由Alu中二联体的关联压力造成的，从而表明这种重复序列对生命活动的多样化起着重要作用。
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| 关 键 词： | Alu序列 非标准剪接 关联压力 多样化 |
| 文章编号： | 1672-5565（2008）-01-03-04 |
| 收稿时间： | 2007-01-27 |
| 修稿时间： | 2007-05-08 |
Study on the splice sites in Alus |
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| LIU Bo,LUO Liao-fu,ZHANG Li-rong,JIN Hong-ying.Study on the splice sites in Alus[J].China Journal of Bioinformation,2008,6(1):3-5,11. |
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| Authors: | LIU Bo LUO Liao-fu ZHANG Li-rong JIN Hong-ying |
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| Institution: | LIU BO, LUO Liao - fu , ZHANG Li - rong, JIN Hong- ying ( College of Sciences and Technology, Inner Mongolia University, Hohot 010021, China) |
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| Abstract: | analysis on the types and distribution of splice sites in Alus indicates that non- standard sites are abundant as a departure from the GT- AG rule. The frequencies of non - standard splice sites vary with chromosomes, such as more residing on chr. 11, 12, 17. By a statistical approach, we found that the splice sites are subject to dinucleotide appearances in Aius, and thereby such repetitive elements have increased the versatility of the genome. |
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| Keywords: | Aiu sequences non - standard splicing correlation pressure versatility |
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