The formation of 1-hydroxymethylnaphthalene and 6-hydroxymethylquinoline by both oxidative and reductive routes in Cunninghamella elegans |
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Authors: | R J Mountfield D J Hopper |
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Institution: | (1) Institute of Biological Sciences, University of Wales, Aberystwyth, Ceredigion SY23 3DD, UK, GB |
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Abstract: | Extraction of medium after incubation of the fungus, Cunninghamella elegans, with 0.03% (w/v) 1-methylnaphthalene produced mainly 1-hydroxymethylnaphthalene together with some 1-naphthoic acid and
hydroxynaphthoic acid. Higher concentrations of substrate were inhibitory to biotransformation. Similar incubations with 1-naphtoic
acid as substrate resulted in reduction of the carboxyl group to give 1-hydroxymethylnaphthalene. When 6-methylquinoline was
used, the main product was 6-hydroxymethylquinoline but also some quinoline-6-carboxylic acid and some 6-methylquinoline-N-oxide were identified. In a 2-l fermenter 2.5 g substrate was transformed in 324 h. The 6-hydroxymethylquinoline was also
produced by reduction of quinoline-6-carboxylic acid by the organism.
Received: 9 March 1998 / Received revision: 15 June 1998 / Accepted: 19 June 1998 |
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