Cutting edge: identification of E-cadherin as a ligand for the murine killer cell lectin-like receptor G1 |
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Authors: | Gründemann Carsten Bauer Monika Schweier Oliver von Oppen Nanette Lässing Ute Saudan Philippe Becker Karl-Friedrich Karp Klaus Hanke Thomas Bachmann Martin F Pircher Hanspeter |
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Institution: | Department of Immunology, Institute of Medical Microbiology and Hygiene, University of Freiburg, Freiburg, Germany. |
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Abstract: | The killer cell lectin-like receptor G1 (KLRG1) is expressed by NK cells and by T cells. In both humans and mice, KLRG1 identifies Ag-experienced T cells that are impaired in their proliferative capacity but are capable of performing effector functions. In this study, we identified E-cadherin as a ligand for murine KLRG1 by using fluorescently labeled, soluble tetrameric complexes of the extracellular domain of the murine KLRG1 molecule as staining reagents in expression cloning. Ectopic expression of E-cadherin in B16.BL6 target cells did not affect cell-mediated lysis by lymphokine-activated NK cells and by CD8 T cells but inhibited Ag-induced proliferation and induction of cytolytic activity of CD8 T cells. E-cadherin is expressed by normal epithelial cells, Langerhans cells, and keratinocytes and is usually down-regulated on metastatic cancer cells. KLRG1 ligation by E-cadherin in healthy tissue may thus exert an inhibitory effect on primed T cells. |
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