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Safe biotechnology. Part 6. Safety assessment,in respect of human health,of microorganisms used in biotechnology |
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| Authors: | H L M Lelieveld H Bachmayer B Boon G Brunius K Bürki A Chmiel C H Collins P Crooy O Doblhoff-Dier I Economidis A Elmqvist W Frommer C Frontali-Botti R Havenaar H Haymerle C Hussey O Käppeli M Lex S Lund J L Mahler R Marris Ch Mosgaard C Normand-Plessier F Rudan R Simon M Th Logtenberg R G Werner |
| Institution: | (1) Institute for Applied Microbiology, University of Agriculture, Nussdorfor-Lände 11, A-1190 Vienna, Austria |
| Abstract: | The assessment of microorganisms in respect to human health is an important step for the introduction of new natural and genetically modified production strains to biotechnology. This report outlines the potential hazards posed by industrial microorganisms, important considerations related to pathogenicity, such as routes and portals of entry into the human body, mechanisms of spread of biological material and a definition of pathogenicity.Furthermore the most important steps in the assessment of pathogenicity of unknown strains are described. A short overview on characterization and in vitro and in vivo tests is presented. The hazard related to allergens and toxic metabolites is reviewed and the choice of methods and the handling of strains with unknown potential are discussed. |
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