Polarity proteins regulate mammalian cell–cell junctions and cancer pathogenesis |
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Authors: | Michael E Feigin Senthil K Muthuswamy |
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Institution: | 1Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, United States;2Ontario Cancer Institute, Campbell Family Institute for Breast Cancer Research, University of Toronto, Toronto, Canada |
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Abstract: | Polarity pathways regulate important functions during the formation and maintenance of cell–cell junctions and during morphogenesis. In addition, cell polarity pathways are emerging as critical regulators of initiation and progression of carcinoma by functioning as tumor suppressors, downstream of oncogenes, or promoters of the metastatic process (Figure 2). It is highly likely that further analysis of cell polarity proteins and the pathways they control will identify novel biomarkers and potential drug targets for managing and treating patients with carcinoma. References and recommended readingPapers of particular interest, published within the period of review, have been highlighted as:- • of special interest
- •• of outstanding interest
AcknowledgementsWe would like to thank Jim Duffy for the artwork. SKM was supported by CA098830 and CA105388 grants from NCI; BC075024 and Era of Hope Scholar award from DOD Breast Cancer Research Program. |
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