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Substituted benzoxazinones as potent positive allosteric AMPA receptor modulators: part II |
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| Authors: | Mueller Rudolf Rachwal Stanislaw Tedder Martina E Li Yong-Xin Zhong Sheng Hampson Aidan Ulas Jolanta Varney Mark Nielsson Lena Rogers Gary |
| Institution: | Cortex Pharmaceuticals Inc., 15231 Barranca Parkway, Irvine, CA 92618, USA |
| Abstract: | AMPA receptors (AMPARs) are an important therapeutic target in the CNS. A series of substituted benzoxazinone derivatives with good to very good in vitro activity as positive allosteric AMPAR modulators was synthesized and evaluated. The appropriate substituent choice on the benzoxazinone fragment improved the affinity towards the AMPA receptor significantly in comparison to our lead molecule CX614. |
| Keywords: | AMPA Receptor Modulator Synthesis |
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