Identification of 4H,6H-[2]benzoxepino[4,5-c][1,2]oxazoles as novel squalene synthase inhibitors |
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| Authors: | Griebenow Nils Buchmueller Anja Kolkhof Peter Schamberger Jens Bischoff Hilmar |
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| Institution: | a Bayer Pharma AG, Global Drug Discovery, Medicinal Chemistry Wuppertal, Building 460, D-42096 Wuppertal, Germany
b Bayer Pharma AG, Global Drug Discovery, Cardiology Research, Building 500, D-42096 Wuppertal, Germany |
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| Abstract: | Novel squalene synthase inhibitors are disclosed. The design, synthesis, SAR and pharmacological profile of the compounds are discussed. |
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| Keywords: | Squalene synthase inhibitor SAR Atherosclerosis 4H 6H-[2]Benzoxepino[4 5-c][1 2]oxazole |
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