Targeted and armed oncolytic adenovirus via chemoselective modification |
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| Authors: | Banerjee Partha S Zuniga Edison S Ojima Iwao Carrico Isaac S |
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| Affiliation: | Department of Chemistry and Institute of Chemical Biology and Drug Discovery, State University of New York at Stony Brook, NY 11790, USA |
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| Abstract: | Oncolytic adenoviruses (Ads) are an emerging alternative therapy for cancer; however, clinical trial have not yet demonstrated sufficient efficacy. When oncolytic Ads are used in combination with taxoids a synergistic increase in both cytotoxicity and viral replication is observed. In order to generate a next generation oncolytic adenovirus, virion were physically conjugated to a highly potent taxoid, SB-T-1214, and a folate targeting motif. Conjugation was enabled via the metabolic incorporation of non-canonical monosaccharides (O-GlcNAz) and amino acids (homopropargylglycine), which served as sites for chemoselective modification. |
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| Keywords: | Non-canonical Unnatural Chemoselective Click Staudinger Adenovirus Taxoid Paclitaxel Oncolytic Gene delivery |
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