Synthesis and antiglycation potentials of bergenin derivatives |
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| Authors: | Vijaya Kumar T Tiwari Ashok K Robinson A Suresh Babu K Sateesh Chandra Kumar R Anand Kumar D Zehra A Madhusudna Rao J |
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| Affiliation: | a Natural Products Laboratory, Indian Institute of Chemical Technology, Uppal Road, Hyderabad 500607, India
b Pharmacology Division, Indian Institute of Chemical Technology, Uppal Road, Hyderabad 500607, India |
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| Abstract: | Bergenin (1), major bioactive compound isolated from methanolic extract of Mallotus philippinensis, displayed moderate AGE inhibition activity (IC50 = 186.73 μM). A series of derivatives of bergenin (3a-k) containing variety of aromatic acids were synthesized under mild conditions by modification of sugar part. Selective esterification of hydroxyl groups on the sugar part enhanced antiglycation potential of bergenin. Compounds 3j and 3k exhibited potent antiglycation activity with the IC50 values of 60.75 and 12.28 μM, respectively. |
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| Keywords: | Bergenin Antiglycation potentials Esters derivatives ABTS· + scavenging activity |
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