|
|||||
|
|
Enzymatic synthesis of a 6-sialyl lactose analogue using a pH-responsive water-soluble polymer support |
|
| Authors: | Wang Wenjun Li Lei Jin Chen Niu Yujie Li Sen Ma Ji Li Linfeng Liu Yu Cai Li Zhao Wei Wang Peng George |
| Institution: | a College of pharmacy, Nankai University, Tianjin 300071, PR China b State Key Laboratory of Elemento-organic Chemistry, Nankai University, Tianjin 300071, PR China c Department of Chemistry and Biochemistry, The Ohio State University, Columbus, OH 43210, USA |
| Abstract: | The Letter describes a strategy for the enzymatic synthesis of glycans based on a pH-responsive water-soluble polymer. In neutral condition, the polymer is water-soluble and convenient for in-solution enzymatic synthesis, whereas in acidic condition (pH lower than 4.0), the polymer disconnects with the product and becomes insoluble, which can be easily removed. A 6-Sialyl lactose analogue was synthesized as a model reaction using this approach. |
| Keywords: | Carbohydrate pH-responsive polymer Enzymatic synthesis |
| 本文献已被 ScienceDirect PubMed 等数据库收录！ | |