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Sannastatin, a novel toxic macrolactam polyketide glycoside produced by actinomycete Streptomyces sannanensis |
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| Authors: | Yang Sheng-Xiang Gao Jin-Ming Zhang An-Ling Laatsch Hartmut |
| Institution: | a Research Centre for Natural Medicinal Chemistry, College of Science, Northwest A&F University, Yangling, Shaanxi 712100, China b Department of Organic Chemistry, University of Goettingen, Tammannstrasse 2, D-37077 Goettingen, Germany c Department of Chemical Engineering, Huainan Union University, Huainan 232038, Anhui, China |
| Abstract: | A new rare 20-membered macrocyclic lactam incorporating a diene conjugated olefin, designated sannastatin (1), together with the known structurally related vicenistatin (2), has been isolated from the cultures of Streptomyces sannanensis, a bacteria found in the feces of Ailuropoda melanoleuca. The structure of the new compound was established on the basis of extensive spectroscopic analyses including 1D- and 2D-NMR (1H-1H COSY, TOCSY, HSQC, HMBC, and NOESY) experiments. Compounds 1 and 2 displayed significant growth inhibitory activity against the brine shrimp (Artemia salina) larvae. |
| Keywords: | Ailuropoda melanoleuca Streptomyces sannanensis Sannastatin 20-Membered macrocyclic lactam Toxic activity |
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