Synthesis and evaluation of antioxidant and antibacterial activities of new substituted bis(1,3,4-oxadiazoles), 3,5-bis(substituted) pyrazoles and isoxazoles |
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Authors: | Abdu Musad Ebraheem Mohamed Riyaz Saeed Bahjat Ali Vishwanath Bannikuppe S Rai K M Lokanatha |
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Institution: | a Department of Studies in Chemistry, University of Mysore, Manasagangotri, Mysore 570 006, India b Department of Studies in Biochemistry, University of Mysore, Manasagangotri, Mysore 570 006, India c Department of Chemistry, College of Education, University of Basrah, Basrah, Iraq |
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Abstract: | Two series of five membered heterocyclic bis(1,3,4-oxadiazole) derivatives 2(a-h) and 3,5-bis(substituted)pyrazoles, isoxazoles 3(a,b,d-i), 4(a-c) were synthesized via oxidative cyclization of some diaroylhydrazones using chloramine-T and cyclocondensation reaction with hydrazine hydrate and hydroxylamine hydrochloride, respectively. The newly synthesized compounds were screened for antioxidant and anti-microbial activities. Compounds 2(b), 3(b), and 4(a) showed higher antioxidant activity at 10 μg/ml while compounds 2(a), 3(a), 3(f), and 4(a) exhibited better anti-microbial activity at 100 μg/ml compared with standard vitamin C and ciprofloxacin, respectively. Structures of newly synthesized compounds were confirmed by elemental analysis and spectral IR, 1H NMR, and 13C NMR data. |
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Keywords: | Methylene-linked bis(1 3 4-oxadiazole) derivatives 3 5-Bis(substituted) pyrazoles Isoxazoles Antioxidant Antibacterial |
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