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Synthesis and discovery of novel hexacyclic cage compounds as inhibitors of acetylcholinesterase |
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| Authors: | Suresh Kumar Raju Ashraf Ali Mohamed Osman Hasnah Ismail Rusli Choon Tan Soo Yoon Yeong Keng Wei Ang Chee Pandian Suresh Manogaran Elumalai |
| Institution: | a School of Chemical Sciences, Universiti Sains Malaysia, Penang 11800, Malaysia b Pharmacogenetic and Pharmacogenomic Research, Institute for Research in Molecular Medicine, Universiti Sains Malysia, Pennag 11800, Malaysia c New Drug Discovery Research, Department of Medicinal Chemistry, Alwar Pharmacy College, Alwar, Rajasthan 301030, India d Karpagam College of Pharmacy, Department of Pharmacology Karpakam University, Coimbatore 641032, Tamil Nadu, India |
| Abstract: | Hexacyclic derivatives share vital pharmacological properties, considered useful in Alzheimer’s disease. The aim of this study was synthesis and its evaluation for acetyl cholinesterase inhibitory activity of novel hexacyclic analogues. Compound 4f, showed potent inhibitory activity against acetyl cholinesterase enzyme with IC50 0.72 μmol/L. |
| Keywords: | Alzheimer Diseases Acetyl cholinesterase AchE inhibitor 1 3-Dipolar cycloaddition Azomethine ylide |
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