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Low-sulphated oligosaccharides derived from heparan sulphate inhibit normal angiogenesis |
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| Authors: | Hahnenberger, Rudolph Jakobson, ke M. Ansari, Akbar Wehler, Thomas Svahn, Carl Magnus Lindahl, Ulf |
| Affiliation: | Department of Ophthalmology, Akademiska Sjukhuset S-751 85 Uppsala 1Department of Pediatrics, Akademiska Barnsjukhuset S-751 85 Uppsala 2KabiPharmacia AB S-112 87 Stockholm 3Department of Medical and Physiological Chemistry, University of Uppsala Box 575, S-751 23 Uppsala, Sweden |
| Abstract: | Heparin, with or without the addition of an adrenocorticosteroid,can inhibit normal angiogenesis in the chick embryo chorioallantoicmembrane. Low- or non-sulphated heparin fragments also haveanti-angiogenic effect. Attempts to define a saccharide structureresponsible for the anti-angiogenic effect implicated a -[GlcAß1,4-GlcNAc |
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