Low-sulphated oligosaccharides derived from heparan sulphate inhibit normal angiogenesis |
| |
Authors: | Hahnenberger Rudolph; Jakobson ke M; Ansari Akbar; Wehler Thomas; Svahn Carl Magnus; Lindahl Ulf |
| |
Institution: | Department of Ophthalmology, Akademiska Sjukhuset S-751 85 Uppsala
1Department of Pediatrics, Akademiska Barnsjukhuset S-751 85 Uppsala
2KabiPharmacia AB S-112 87 Stockholm
3Department of Medical and Physiological Chemistry, University of Uppsala Box 575, S-751 23 Uppsala, Sweden |
| |
Abstract: | Heparin, with or without the addition of an adrenocorticosteroid,can inhibit normal angiogenesis in the chick embryo chorioallantoicmembrane. Low- or non-sulphated heparin fragments also haveanti-angiogenic effect. Attempts to define a saccharide structureresponsible for the anti-angiogenic effect implicated a -GlcAß1,4-GlcNAc |
| |
Keywords: | |
本文献已被 Oxford 等数据库收录! |
|