| Nogo与Nogo受体研究 |
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| 引用本文： | 吴兰香,孙长凯,范明.Nogo与Nogo受体研究[J].生物化学与生物物理进展,2002,29(6):834-836. |
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| 作者姓名： | 吴兰香 孙长凯 范明 |
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| 作者单位： | 1. 大连医科大学脑疾病研究所,大连,116027
2. 军事医学科学院基础医学研究所,北京,100850 |
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| 摘 要： | nogo是新近发现的一种基因，编码3种蛋白质：Nogo-A、Nogo-B和Nogo-C.迄今为止，已证明它有抑制成熟中枢神经系统(CNS)神经元轴突再生及诱导细胞凋亡的作用.Nogo受体是一种糖基醇磷脂结合蛋白.对Nogo和Nogo受体的研究，对于CNS再生障碍及肿瘤的认识和治疗有重要意义.
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| 关 键 词： | 神经再生，细胞凋亡，Nogo，Nogo受体 |
| 收稿时间： | 9/4/2002 12:00:00 AM |
| 修稿时间： | 2002年9月4日 |
Nogo and Nogo Receptor |
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| WU Lan-Xiang,SUN Chang-Kai and FAN Ming.Nogo and Nogo Receptor[J].Progress In Biochemistry and Biophysics,2002,29(6):834-836. |
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| Authors: | WU Lan-Xiang SUN Chang-Kai and FAN Ming |
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| Institution: | Institute for Brain Disorders, Dalian Medical University, Dalian 116027, China;Institute for Brain Disorders, Dalian Medical University, Dalian 116027, China;Institute of Basic Medical Science, Academy of Military Medical Sciences, Beijing 100850, China |
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| Abstract: | nogo is a recently discovered gene. It mainly encodes three proteins: Nogo-A, Nogo-B and Nogo-C. To date, it has been proved to be associated with axonal outgrowth inhibition in mature central nervous system(CNS) and apoptosis-inducing. Nogo receptor is a glycosylphosphatidylinositol(GPI)-anchored protein. To investigate the Nogo and Nogo receptor is important for understanding of neurite outgrowth inhibition following CNS injury and cancer. |
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| Keywords: | neural regeneration apoptosis Nogo Nogo receptor |
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