首页 | 本学科首页   官方微博 | 高级检索  
     


Genome-Wide Association Study of Pancreatic Cancer in Japanese Population
Authors:Siew-Kee Low  Aya Kuchiba  Hitoshi Zembutsu  Akira Saito  Atsushi Takahashi  Michiaki Kubo  Yataro Daigo  Naoyuki Kamatani  Suenori Chiku  Hirohiko Totsuka  Sumiko Ohnami  Hiroshi Hirose  Kazuaki Shimada  Takuji Okusaka  Teruhiko Yoshida  Yusuke Nakamura  Hiromi Sakamoto
Abstract:Pancreatic cancer shows very poor prognosis and is the fifth leading cause of cancer death in Japan. Previous studies indicated some genetic factors contributing to the development and progression of pancreatic cancer; however, there are limited reports for common genetic variants to be associated with this disease, especially in the Asian population. We have conducted a genome-wide association study (GWAS) using 991 invasive pancreatic ductal adenocarcinoma cases and 5,209 controls, and identified three loci showing significant association (P-value<5×10−7) with susceptibility to pancreatic cancer. The SNPs that showed significant association carried estimated odds ratios of 1.29, 1.32, and 3.73 with 95% confidence intervals of 1.17–1.43, 1.19–1.47, and 2.24–6.21; P-value of 3.30×10−7, 3.30×10−7, and 4.41×10−7; located on chromosomes 6p25.3, 12p11.21 and 7q36.2, respectively. These associated SNPs are located within linkage disequilibrium blocks containing genes that have been implicated some roles in the oncogenesis of pancreatic cancer.
Keywords:
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号