Development and homeostasis of the sebaceous gland |
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| Authors: | Catherin Niemann Valerie Horsley |
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| Affiliation: | 1. Center for Molecular Medicine Cologne, University of Cologne, Germany;2. Department of Molecular, Cellular and Developmental Biology, Yale University, New Haven, USA;1. Department of Pharmaceutical Technology, Poznan University of Medical Sciences, Grunwaldzka 6, 60-780 Poznań, Poland;2. Department of Pharmaceutical Technology, Medical University of Gdansk, Hallera 107, 80-416 Gdańsk, Poland;3. Institute of Chemical Technology and Engineering, Poznan University of Technology, Berdychowo 4, 60-695 Poznań, Poland;4. Department of Biopharmaceutics and Pharmacodynamics, Medical University of Gdansk, Hallera 107, 80-416 Gdańsk, Poland;5. Department of Pharmaceutical Technology, Faculty of Pharmacy, University of Ljubljana, A?ker?eva 7, SI-1000 Ljubljana, Slovenia;6. Dr Irena Eris Centre for Science and Research, Pu?awska 107 A, 02-595 Warsaw, Poland;1. Department of Experimental Surgery, Lausanne University Hospital (CHUV), 1011 Lausanne, Switzerland;2. Laboratory of Stem Cell Dynamics, Ecole Polytechnique Fédérale de Lausanne (EPFL), 1015 Lausanne, Switzerland;3. Department of Cell Growth and Tumor Regulation, Proteo-Medicine Research Center, Ehime University, Shitsukawa, Toon, Ehime 791-0295, Japan;1. Black Family Stem Cell Institute, Mount Sinai School of Medicine, New York, NY 10029, USA;2. Department of Developmental and Regenerative Biology, Mount Sinai School of Medicine, New York, NY 10029, USA;3. Department of Dermatology, Mount Sinai School of Medicine, New York, NY 10029, USA;1. Clinical Pharmacology and Toxicology Unit, University of Geneva, Geneva, Switzerland;2. Clinical Skin Research Centre, Pierre Fabre Dermo-Cosmétique, Toulouse, France;3. Dermatology Department, Toulouse University Hospital, Toulouse, France;4. Pharmacology Department, Pierre Fabre Dermo-Cosmétique, Toulouse, France;1. Institute of Molecular Animal Breeding and Biotechnology, Gene Center, LMU Munich, Munich, Germany;2. Laboratory for Functional Genome Analysis (LAFUGA), Gene Center, LMU Munich, Munich, Germany;3. Departments of Dermatology, Venereology, Allergology and Immunology, Dessau Medical Center, Dessau, Germany;1. Skin Research Institute of Singapore, Agency for Science, Technology and Research, Singapore, Singapore;2. Lee Kong Chian School of Medicine, Nanyang Technological University Singapore, Singapore, Singapore |
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| Abstract: | The important role of epidermal appendages especially the sebaceous gland has only recently been recognized. In particular, it has been convincingly shown that normal development and maintenance of the sebaceous gland are required for skin homeostasis since atrophic sebaceous glands and disturbances in sebaceous lipid composition result in major defects of the physiological barrier and maintenance of the skin. Consequently, it is important to unravel the signaling network controlling proper sebaceous lineage differentiation in mammalian skin and to understand the underlying mechanisms leading to severe skin diseases, including abnormal proliferation and differentiation of the gland, defects of the lipid metabolism and barrier, as well as sebaceous tumor formation. Over the last years, results from transgenic and knock out mouse models manipulating distinct signaling pathways in the skin as well as the detailed analysis of human sebaceous gland-derived cell lines provided new insights into crucial mediators balancing proliferation and differentiation of the sebaceous gland. Here, we discuss our current knowledge of in vivo mechanisms of sebaceous gland development, maintenance and disorders and highlight recent contributions to the field of sebaceous gland biology. |
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