DNA fusion vaccines against B-cell tumors |
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Authors: | Delin Zhu Jason Rice Natalia Savelyeva Freda K Stevenson |
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Institution: | Molecular Immunology Group, Tenovus Laboratory, Southampton University Hospitals Trust, Southampton, UK SO16 6YD. dz1@soton.ac.uk |
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Abstract: | DNA vaccination is currently being explored as a potential strategy for combatting cancer. However, tumor antigens are often weak and the immune system of patients may be compromised. For B-cell tumors, immunoglobulin idiotypic antigens provide defined targets but are poorly immunogenic. Fusion of a sequence derived from tetanus toxin to the genes encoding idiotypic determinants has proved highly effective in activating protective anti-tumor immunity. DNA fusion vaccines containing immuno-enhancing sequences can augment and direct immune attack on a range of target antigens. Gene-based fusion vaccines offer ease of manipulation and flexible design to activate effective attack on cancer. |
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Keywords: | DNA vaccine tetanus toxin fusion vaccine B-cell tumor lymphoma myeloma |
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