P53，Rb和c－myc基因在人脑原发性肿瘤中的转录表达

采用ＲＮＡ斑点杂交分析，对２１测人脑原发性胶质瘤和１１例人脑膜瘤中ｐ５３，Ｒｂ和ｃ－ｍｙｃ基因转录水平的表达进行研究，发现４８．４％的肿瘤中ｐ５３基因表达减弱，２１．９％的肿瘤中Ｒｂ基因表达减弱；７１．９％的肿瘤中ｃ－ｍｙｃ基因表达增强，在ｐ５３基因表达减弱的１５例病例中有１３例（８０％）ｃ－ｍｙｃ基因表达增强，结果表明，ｐ５３基因表达减弱和ｃ－ｍｙｃ基因表达增强与人脑原发性肿瘤的发生有关。

The Expression of p53. Rb and c-myc Gene mRNA in Human Primary Brain Tumor

21 human primary brain gliomas and 11 human menigiomas were examined with RNA dot blot hybridization for the expression of p53, Rb and c-myc gene. It was found that the level of p53 gene expression is lower in 48.4% (15/31) of the tumors tested than that of normal brain tissues; the level of Rb gene expression is lower in 21.9% (7/32) for the tumors tested than that of normal tissues; and the level of c-myc gene expression is higher in 71.9% (23/32) for the tumors tested than that of normal tissues. Interestingly, in 13 of the tumors tested, the level of p53 gene expression is lower and the level of c-myc gene expression is higher. These results suggested that the expressive decrease of p53 gene and the expressive increase of c-myc gene are relative to the generation of human primary brain tumor.