Novel imidazo[1,2-a]pyrazine derivatives as potent reversible inhibitors of the gastric H+/K+-ATPase |
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Authors: | Zimmermann Peter Jan Brehm Christof Buhr Wilm Palmer Andreas Marc Volz Jürgen Simon Wolfgang-Alexander |
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Institution: | Nycomed GmbH, Byk-Gulden-Str. 2, D-78467 Konstanz, Germany. pjz@lycos.de |
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Abstract: | A series of novel 6-substituted imidazo1,2-a]pyrazines were synthesized via palladium catalyzed amino- or alkoxycarbonylation as key step. The anti-secretory activity of these compounds has been assessed in a binding assay against H(+)/K(+)-ATPase from hog gastric mucosa. Some of the compounds proved to be potent inhibitors of the gastric acid pump. |
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