Suppression of RNA interference increases alphavirus replication and virus-associated mortality in Aedes aegypti mosquitoes |
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| Authors: | Chris M Cirimotich Jaclyn C Scott Aaron T Phillips Brian J Geiss and Ken E Olson |
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| Institution: | (1) Arthropod-Borne and Infectious Diseases Laboratory, Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO 80523, USA;(2) Department of Biochemistry and Molecular Biology, Colorado State University, Fort Collins, CO 80523, USA;(3) Department of Molecular Microbiology and Immunology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205, USA |
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| Abstract: | Background Arthropod-borne viruses (arboviruses) can persistently infect and cause limited damage to mosquito vectors. RNA interference
(RNAi) is a mosquito antiviral response important in restricting RNA virus replication and has been shown to be active against
some arboviruses. The goal of this study was to use a recombinant Sindbis virus (SINV; family Togaviridae; genus Alphavirus) that expresses B2 protein of Flock House virus (FHV; family Nodaviridae; genus Alphanodavirus), a protein that inhibits RNAi, to determine the effects of linking arbovirus infection with RNAi inhibition. |
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