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Spatial restriction of bone morphogenetic protein signaling in mouse gastrula through the mVam2-dependent endocytic pathway
Authors:Aoyama Minako  Sun-Wada Ge-Hong  Yamamoto Akitsugu  Yamamoto Masamichi  Hamada Hiroshi  Wada Yoh
Affiliation:1. Division of Biological Science, Institute of Scientific and Industrial Research, Osaka University, 8-1 Mihogaoka, Ibaraki, Osaka 567-0047, Japan;2. Faculty of Pharmaceutical Sciences, Doshisha Women''s College of Liberal Arts, Kohdo, Kyotanabe, Kyoto 610-0395, Japan;3. Department of Cell Biology, Nagahama Institute of Bio-Science and Technology, 1266 Tamura, Nagahama, Shiga 526-0829, Japan;4. Developmental Genetics Group, Graduate School of Frontier Biosciences, Osaka University, 1-3 Yamadaoka, Suita, Osaka 565-0871, Japan;5. Core Research of Evolutional Science & Technology, Japan Science and Technology Agency, K''s Gobancho 6F, 7 Gobancho, Chiyoda-ku, Tokyo 102-0076, Japan
Abstract:
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  • Highlights? mVam2 mediates endocytic transport from late endosomes to lysosomes ? mVam2 is essential for assembly of large apical vacuoles in visceral endoderm ? Loss of mVam2 results in hyperactivation of BMP signaling ? The mVam2-dependent BMP attenuation contributes to patterning in gastrulation
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