Mating between two balanced translocation carriers in two unrelated families |
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Authors: | B. Dallapiccola L. Chessa V. Brinchi M. Frontali E. Gandini |
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Affiliation: | 1. Cattedra di Genetica Umana, Università di Urbino, Urbino, Italia 2. Cattedra di Genetica Medica, Università “La Sapienza”, Roma, Italia
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Abstract: | Partial trisomy 9p and a 13/14 translocation occurred in the daughter of a t(5;9)(p15;p12) mother and a t(13;14)(p11;q11) father. Two additional offspring displayed a normal karyotype and a translocation trisomy 13 respectively. Two first cousins, selected for chromosome analysis because of a spontaneous abortion, were found to have an identical translocation t(14;21)(p11;q11). Their second pregnancy was monitored by midtrimester amniocentesis and disclosed a balanced fetus. The different zygotic chromosome constitutions and the counselling problems in the marriages between two balanced translocation carriers are discussed. |
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