| 印度红树植物Xylocarpus moluccensis的柠檬苦素 |
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| 引用本文： | 曲栋,张群,申丽,汪志刚.印度红树植物Xylocarpus moluccensis的柠檬苦素[J].天然产物研究与开发,2021(1):57-64. |
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| 作者姓名： | 曲栋 张群 申丽 汪志刚 |
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| 作者单位： | 暨南大学药学院;暨南大学附属第一医院 |
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| 基金项目： | 国家自然科学基金(31770377);广东省自然科学基金杰出青年项目(2020B1515020056)。 |
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| 摘 要： | 对采集自印度安得拉邦克里希纳港湾红树林湿地的木果楝属红树植物X.moluccensis种子中的柠檬苦素进行了研究,利用95％乙醇提取、乙酸乙酯萃取、正反相硅胶柱层析和高效液相色谱等手段进行分离制备得到11个化合物.通过核磁共振波谱和离子阱电喷雾质谱鉴定结构,全部化合物均为首次从该植物中分离得到,其中化合物1为一个新的墨...
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| 关 键 词： | 红树植物 Xylocarpus moluccensis 柠檬苦素 墨西哥交酯 人羧酸酯酶2 |
Limonoids from Indian mangrove,Xylocarpus moluccensis |
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| QU Dong,ZHANG Qun,SHEN Li,WANG Zhi-gang.Limonoids from Indian mangrove,Xylocarpus moluccensis[J].Natural Product Research and Development,2021(1):57-64. |
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| Authors: | QU Dong ZHANG Qun SHEN Li WANG Zhi-gang |
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| Institution: | (College of Pharmacy,Jinan University;The First Affiliated Hospital,Jinan University,Guangzhou 510632,China) |
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| Abstract: | Limonoids from the seeds of Xylocarpus moluccensis,collected in the mangrove swamp of Krishna estuary,Andhra Pradesh in India,were investigated.Eleven compounds were isolated and purified by extraction with 95%ethanol,and ethyl acetate,silica gel,ODS gel column chromatography,and high performance liquid chromatography(HPLC).The structures were confirmed by NMR spectra,and ESI-MS.All compounds were isolated for the first time from X.moluccensis,and compound 1 was identified as a new mexicanolide limonoid,named krishnolide E.Furthermore,compound 1 exhibited inhibitory effect on human carboxylesterase 2(CES2)with inhibition rate of 63%at the concentration of 100.0μM. |
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| Keywords: | mangrove Xylocarpus moluccensis limonoid mexicanolide human carboxylesterase 2(CES2) |
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