| 缺血/缺氧对自发性高血压大鼠肠系膜动脉血管舒缩功能的影响及其可能机制 |
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| 作者姓名： | Zhao M Yu XJ Zhang HL Bi XY Hu H Zang WJ |
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| 作者单位： | 西安交通大学医学院药理学系; |
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| 基金项目： | supported by Major International(Regional)Joint Research Project of National Natural Science Foundation of China(No.81120108002); National Natural Science Foundation of China(No.30930105;No.30873058); China Medical Board Distinguished Professorships Award(No.F510000/G16916404) |
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| 摘 要： | 高血压引起的脑卒中、冠心病等严重并发症的发生,均与组织缺血/缺氧导致的动脉血管痉挛有关。为了研究高血压大鼠肠系膜血管缺血/缺氧后的功能学改变,本研究采用三气培养箱模拟缺血/缺氧条件处理自发性高血压大鼠(spontaneously hypertensive rats,SHR)肠系膜动脉血管环,运用敏感的肌张力描记技术测定血管环对不同血管活性物质的反应性。结果显示:与WKY组大鼠相比,SHR组大鼠肠系膜动脉血管对收缩剂KCl和苯肾上腺素(phenylephrine,PE)的反应性明显提高,对内皮依赖的血管舒张剂乙酰胆碱(acetylcholine,ACh)的反应性显著降低;而与SHR组和急性缺血/缺氧对照(WKY+H)组相比较,高血压合并急性缺血/缺氧(SHR+H)组对KCl和PE的收缩反应显著性增加,对ACh的舒张反应明显降低。N-硝基-L-精氨酸甲酯(L-NAME)存在时,SHR+H组和SHR组血管环对ACh的舒张反应没有明显变化,而WKY组血管对ACh的舒张反应显著降低。与SHR组相比,SHR+H组CaCl2诱导的钙依赖性收缩曲线明显左移。在无钙K-H液中,SHR+H组PE和咖啡因(caffeine)诱导的...
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| 关 键 词： | 高血压 缺氧 缺血 内皮功能紊乱 钙 组织培养技术 |
Effect of ischemia/hypoxia on mesenteric vasomotor function in spontaneously hypertensive rats and its possible mechanism |
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| Zhao M,Yu XJ,Zhang HL,Bi XY,Hu H,Zang WJ.Effect of ischemia/hypoxia on mesenteric vasomotor function in spontaneously hypertensive rats and its possible mechanism[J].Acta Physiologica Sinica,2011,63(6):540-548. |
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| Authors: | Zhao Ming Yu Xiao-Jiang Zhang Hong-Li Bi Xue-Yuan Hu Hao Zang Wei-Jin |
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| Institution: | ZHAO Ming,YU Xiao-Jiang,ZHANG Hong-Li,BI Xue-Yuan,HU Hao,ZANG Wei-Jin Department of Pharmacology,School of Medicine,Xi'an Jiaotong University,Xi'an 710061,China |
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| Abstract: | Hypertension is a common cardiovascular disease and can induce many complications,such as stroke and coronary heart disease.The purpose of the present study was to investigate the effect of ischemia/hypoxia on mesenteric artery vasomotor function in spontaneously hypertensive rats (SHR).Rat mesenteric arterial rings were cultured in modified ischemia-mimetic solution in a hypoxia incubator for a certain time period.Isometric tension changes of isolated mesenteric arterial rings were recorded continuously by... |
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| Keywords: | hypertension hypoxia ischemia endothelial dysfunction calcium tissue culture techniques |
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