| 低氧预适应大鼠脑脊液减轻氧糖剥夺对培养新生鼠海马神经元的损伤及可能的机制 |
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| 引用本文： | Niu JZ,Zhang YB,Li MY,Liu LL. 低氧预适应大鼠脑脊液减轻氧糖剥夺对培养新生鼠海马神经元的损伤及可能的机制[J]. 生理学报, 2011, 63(6): 491-497 |
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| 作者姓名： | Niu JZ Zhang YB Li MY Liu LL |
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| 作者单位： | 泰山医学院附属医院神经内科;山东泰山慢性病医院神经内科; |
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| 基金项目： | supported by the Natural Science Foundation of Shandong Province,China(No.ZR2010HM029); Medical Science Technology Development Program of Shandong Province,China(No.2009HZ096); Scientific Research Development Program of the Department of Education,Shandong Province,China(No.J08LG71); Technology Development Program of Taian Municipality,China(No.2007t037) |
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| 摘 要： | 本文旨在观察低氧预适应(hypoxic preconditioning,HPC) Wistar大鼠脑脊液对新生鼠海马神经元氧糖剥夺(oxygen glucose deprivation,OGD)损伤的影响及机制.原代培养大鼠新生鼠(出生12 h)海马神经元,随机分为正常对照组、OGD组(OGD培养1.5 h)、正常脑脊...
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| 关 键 词： | 低氧预适应 脑脊液 海马神经元 Bcl-2/Bax |
Lessening effect of hypoxia-preconditioned rat cerebrospinal fluid on oxygen-glucose deprivation-induced injury of cultured hippocampal neurons in neonate rats and possible mechanism |
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| Niu Jing-Zhong,Zhang Yan-Bo,Li Mei-Yi,Liu Li-Li. Lessening effect of hypoxia-preconditioned rat cerebrospinal fluid on oxygen-glucose deprivation-induced injury of cultured hippocampal neurons in neonate rats and possible mechanism[J]. Acta Physiologica Sinica, 2011, 63(6): 491-497 |
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| Authors: | Niu Jing-Zhong Zhang Yan-Bo Li Mei-Yi Liu Li-Li |
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| Affiliation: | NIU Jing-Zhong 1,ZHANG Yan-Bo 1,LI Mei-Yi 2,LIU Li-Li 2 1 Department of Neurology,Affiliated Hospital of Taishan Medical College,Taian 271000,China,2 Department of Neurology,Taishan Chronic Disease Hospital |
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| Abstract: | The present study was to investigate the effect of cerebrospinal fluid (CSF) from the rats with hypoxic preconditioning (HPC) on apoptosis of cultured hippocampal neurons in neonate rats under oxygen glucose deprivation (OGD).Adult Wistar rats were exposed to 3 h of hypoxia for HPC,and then their CSF was taken out.Cultured hippocampal neurons from the neonate rats were randomly divided into four groups (n=6):normal control group,OGD group,normal CSF group and HPC CSF group.OGD group received 1.5 h of incuba... |
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| Keywords: | hypoxia-preconditioning cerebrospinal fluid hippocampal neurons oxygen glucose deprivation Bcl-2/Bax |
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