| MEN1胰岛瘤中细胞周期蛋白cyclin B2高表达的作用和机制 |
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| 作者姓名： | Wu T Huang XH |
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| 作者单位： | 厦门大学医学院基础医学部; |
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| 基金项目： | supported by the Fundamental Research Funds for the Central Universities of China(No.2010121105) |
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| 摘 要： | 多发性内分泌肿瘤1-(multiple endocrine neoplasia type 1,MEN1)是一种常染色体显性遗传的肿瘤综合征,患者常表现出多发性的内分泌器官肿瘤,包括垂体瘤、甲状旁腺瘤和胰岛瘤.抑癌基因Men1的突变导致MENl的发生,其编码的蛋白为核蛋白menin.Menin可以抑制包括胰岛β细胞在内的...
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| 关 键 词： | 胰岛瘤 cyclin B2 有丝分裂 细胞增殖 menin |
The role and mechanism of high expression of cyclin B2 in MEN1 insulinoma |
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| Wu T,Huang XH.The role and mechanism of high expression of cyclin B2 in MEN1 insulinoma[J].Acta Physiologica Sinica,2011,63(6):555-564. |
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| Authors: | Wu Ting Huang Xiao-Hua |
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| Institution: | WU Ting,HUANG Xiao-Hua Department of Basic Medical Sciences,Medical College,Xiamen University,Xiamen 361005,China |
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| Abstract: | Multiple endocrine neoplasia type 1 (MEN1) is a dominantly inherited tumor syndrome characterized by development of various combinations of tumors in multiple endocrine glands,including the pituitary,parathyroid or pancreas.MEN1 results from mutations in tumor suppressor gene Men1,which encodes nuclear protein menin.Menin has been shown to preferentially repress cell proliferation in endocrine tissues including pancreatic beta cells.Herein,the present study was to explore the potential mechanisms underlying... |
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| Keywords: | insulinoma cyclin B2 mitosis cell proliferation menin |
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