| 酒精诱导小鼠海马齿状回神经细胞的增殖:神经酰胺的可能作用 |
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| 引用本文： | Deng TX,Wang ZX,Gao XQ,Shi YY,Ma ZY,Jin HX,Deng JB. 酒精诱导小鼠海马齿状回神经细胞的增殖:神经酰胺的可能作用[J]. 生理学报, 2011, 63(6): 479-490 |
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| 作者姓名： | Deng TX Wang ZX Gao XQ Shi YY Ma ZY Jin HX Deng JB |
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| 作者单位： | 河南大学神经生物学研究所;郑州大学基础医学院人体解剖学教研室;漯河医学高等专科学校人体解剖学教研室; |
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| 基金项目： | supported by the National Natural Science Foundation of China(No.30771140,31070952); Natural Science Research Project of Department of Education,Henan Province,China(No.2007180008); International Collaborative Project of Department of Science and Technology,Henan Province,China(No.094300510044); Basic Research Project of Natural Science,Henan University,China(No.2008YBZR034) |
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| 摘 要： | 本文旨在探讨神经酰胺(ceramide,Cer)在酒精诱导神经细胞增殖及新生神经元形成过程中的作用及机制.因为Cer主要的代谢途径是经神经鞘磷脂合成酶(sphingomyelin synthase,SMS)作用转化成神经鞘磷脂(sphingomyelin,SM),所以我们用SMS2基因敲除(sphingomyelin ...
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| 关 键 词： | 神经酰胺 神经细胞增殖 神经鞘磷脂合成酶2 神经酰胺-1-磷酸 |
Alcohol-induced proliferation of neurons in mouse hippocampal dentate gyrus: a possible role of ceramide |
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| Deng Tong-Xing,Wang Zhi-Xin,Gao Xiao-Qun,Shi Yuan-Yuan,Ma Zhan-You,Jin Hai-Xiao,Deng Jin-Bo. Alcohol-induced proliferation of neurons in mouse hippocampal dentate gyrus: a possible role of ceramide[J]. Acta Physiologica Sinica, 2011, 63(6): 479-490 |
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| Authors: | Deng Tong-Xing Wang Zhi-Xin Gao Xiao-Qun Shi Yuan-Yuan Ma Zhan-You Jin Hai-Xiao Deng Jin-Bo |
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| Affiliation: | DENG Tong-Xing 1,2,3,WANG Zhi-Xin 1,GAO Xiao-Qun 2,SHI Yuan-Yuan 1,MA Zhan-You 1,JIN Hai-Xiao 1,DENG Jin-Bo 1,1 Institute of Neurobiology of Henan University,Kaifeng 475004,China,2 Department of Anatomy,Basic Medical College,Zhengzhou University,Zhengzhou 450052,3 Department of Anatomy of Luohe Medical College,Luohe 462002 |
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| Abstract: | To investigate the role and mechanism of ceramide (Cer) regulation in alcohol-induced neuronal proliferation and the newborn neurons formation,we used sphingomyelin synthase 2 (predominant enzyme of Cer metabolism) knockout (SMS2/) and wild type (WT) female mice to establish the model of prenatal alcohol exposure.In 24 h after being given birth (postnatal day 0,P0),the offspring of model mice received blood sphingomyelin (SM) measurement with enzymatic method.On P0,P7,P14 and P30,the proliferation of granul... |
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| Keywords: | ceramide neural cell proliferation sphingomyelin synthase 2 ceramide-1-phosphate |
| 本文献已被 CNKI PubMed 等数据库收录！ |
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