| 自分泌运动因子-溶血磷脂酸轴的生物学功能与调控 |
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| 作者姓名： | Li ZW Zhao YR Zhao C Fu R Li ZY |
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| 作者单位： | 山西大学生物技术研究所化学生物学与分子工程教育部重点实验室; |
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| 基金项目： | supported by the National Natural Science Foundation of China(No.31040018) |
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| 摘 要： | 自分泌运动因子(autotaxin,ATX)也称作磷酸二酯酶Iα,是核苷酸焦磷酸酶/磷酸二酯酶家族(nucleotide pyrophosphatases,NPPs)中的一员,因而也称作NPP2.ATX是NPPs中唯一具有溶血磷脂酶D(lysophospholipase D,lysoPLD)活性的成员,它可以将溶血磷脂...
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| 关 键 词： | 自分泌运动因子 溶血磷脂酶D 溶血磷脂酸 |
Function and biological activities of the autotaxin-LPA axis |
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| Li ZW,Zhao YR,Zhao C,Fu R,Li ZY.Function and biological activities of the autotaxin-LPA axis[J].Acta Physiologica Sinica,2011,63(6):601-610. |
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| Authors: | Li Zong-Wei Zhao Ya-Rui Zhao Chao Fu Rong Li Zhuo-Yu |
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| Institution: | LI Zong-Wei,ZHAO Ya-Rui,ZHAO Chao,FU Rong,LI Zhuo-Yu Institute of Biotechnology,Key Laboratory of Chemical Biology and Molecular Engineering of National Ministry of Education,Shanxi University,Taiyuan 030006,China |
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| Abstract: | Autotaxin (ATX), a member of nucleotide pyrophosphatase/phosphodiesterase (NPP) family, is also named as phosphodiesterase Iα (PD-Iα) or NPP2. ATX is the unique member among the NPPs that can function as a lysophospholipase D (lysoPLD), converting lysophosphatidylcholine into lysophosphatidic acid (LPA). LPA acts on specific G-protein-coupled receptors to elicit a wide range of cellular response, including cell proliferation, cell migration and cell contraction, etc. As the major LPA-producing phospholipase, many ATX's features and functions are dependent on the production of LPA. ATX and LPA together form the ATX-LPA functional axis. The present review summarizes the current progress in function and biological activities of ATX-LPA axis. |
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| Keywords: | autotoxin lysophospholipase D lysophosphatidic acid |
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