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A potent and orally active HIV-1 integrase inhibitor |
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| Authors: | Egbertson Melissa S Moritz H Marie Melamed Jeffrey Y Han Wei Perlow Debra S Kuo Michelle S Embrey Mark Vacca Joseph P Zrada Matthew M Cortes Amanda R Wallace Audrey Leonard Yvonne Hazuda Daria J Miller Michael D Felock Peter J Stillmock Kara A Witmer Marc V Schleif William Gabryelski Lori J Moyer Gregory Ellis Joan D Jin Lixia Xu Wei Braun Matthew P Kassahun Kellem Tsou Nancy N Young Steven D |
| Affiliation: | Department of Medicinal Chemistry, Merck Research Laboratories, West Point, PA 19486, USA. melissa_egbertson@merck.com |
| Abstract: | A 1,6-naphthyridine inhibitor of HIV-1 integrase has been discovered with excellent inhibitory activity in cells, good pharmacokinetics, and an excellent ability to inhibit virus with mutant enzyme. |
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