MicroRNA调控动物脂肪细胞的分化

MicroRNA (miRNA)属于非编码小调节RNA，在动物细胞的增殖、分化、凋亡和代谢等许多生物学过程中具重要作用.研究显示大量miRNA也参与动物脂肪细胞的分化调节，在前体脂肪细胞向成熟脂肪细胞的分化过程中具有多种功能.目前的研究结果表明，这些miRNA在脂肪细胞分化的早期或后期通过其靶基因发挥功能，如miR-17-92和miR-143分别通过其靶基因Rb 2/p 130和ERK 5/BMK 1调节脂肪细胞分化，过表达可促进体外培养的脂肪细胞分化.因此，了解更多miRNA在脂肪细胞分化中的功能，可以加深对动物脂肪形成分子机制的理解，并有可能将其作为脂类代谢性疾病治疗的潜在靶点.

MicroRNAs Regulate Animals Adipocyte Differentiation

MicroRNAs (miRNAs) are small，non-coding regulatory RNAs that play important roles in many biological processes in mammalian cells, including proliferation, differentiation, apoptosis and metabolism. The present studies implicated that a number of miRNAs participated in the regulation of adipocyte differentiation and played various roles during the differentiation processes from pre-adipocyte to mature adipocyte. These miRNAs function through binding to the target genes at both early or later stage of differentiation. For example, the over-expression of miR-17-92 and miR-143 promote adipocyte differentiation in the cell culture systems by binding to target gene Rb2/p130 and ERK5/BMK, respectively. Therefore, understanding the functions of more miRNAs in adipocyte differentiation will help to explore the molecular mechanism of fat formation, and might lead to the discovery of potential therapeutic targets for lipid metabolicdiseases.