Structural requirement for the action of leukotriene B4 on the guinea-pig lung:importance of double bond geometry in the 6, 8, 10-triene unit期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

按检索

Structural requirement for the action of leukotriene B4 on the guinea-pig lung:importance of double bond geometry in the 6, 8, 10-triene unit

Authors:	P Sirois S Roy P Borgeat S Picard E J Corey

Institution:	Unité de Recherche Pulmonaire, Faculté de Médecine Université de Sherbrooke, Sherbrooke, P.Q., Canada;Groupe de Recherche en Endocrinologie Moléculaire CHUL, Québec, Canada;Dept. of Chemistry, Harvard University, Cambrige, Mass. 02138, U.S.A.

Abstract:	The action of four synthetic 5(S), 12(R)-dihydroxy-6,8,10,14-eicosatetraenoic acids has been compared to the action of natural leukotriene B₄ (LTB₄) in perfused guinea-pig lung and in the parenchymal strip preparations. Synthetic LTB₄ (Fig. 1) having the 6- $cis$ , 8, 10- $trans$ triene unit was found to be as powerful as natural LTB₄ both for contracting the parenchymal strip and for releasing prostaglandins and thromboxanes from the perfused lung while three other isomers were inactive. The results indicate that the action of LTB₄ on the lung is highly dependent on the geometry of the conjugated triene.

Keywords:
本文献已被 ScienceDirect PubMed 等数据库收录！