Erythropoietin in Cerebrospinal Fluid: Age-related Reference Values and Relevance in Neurological Disease |
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Authors: | Karin Widl Johannes Brettschneider Dagmar Schattauer Sigurd Süßmuth Roman Huber Albert C. Ludolph Hayrettin Tumani |
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Affiliation: | (1) Department of Neurology, University of Ulm, Oberer Eselsberg 45, 89081 Ulm, Germany |
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Abstract: | We aimed to establish age-related reference values for Erythropoietin (EPO) in cerebrospinal fluid (CSF) and to evaluate concentrations in neurological diseases. CSF and serum EPO was measured in controls with tension-type headache (CTTH), in patients with ALS, dementia and depression using ELISA technique. Stability experiments showed CSF EPO to be stable for two and a half months and over two thaw/freeze cycles. A positive correlation of CSF EPO with age was found (P < 0.01). We found a CSF/serum EPO concentration ratio of 0.126, pointing towards an intrathecal synthesis of EPO. The ALS group showed significantly lowered CSF EPO compared to age-matched CTTH (P < 0.012), whereas the dementia and depression group showed no significant differences compared to CTTH. The establishment of age-related reference values in a large cohort of controls will improve the interpretation of future CSF EPO evaluations in neurological diseases. The authors have not reported any conflicts of interest. |
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Keywords: | Erythropoietin Cerebrospinal fluid Reference values Age-relation |
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