2,4,6-trinitrotoluene as a trigger of oxidative stress in Fagopyrum tataricum callus cells |
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| Authors: | E A Naumenko G V Sibgatullina A R Mukhitov A A Rodionov O N Il’inskaya R P Naumova |
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| Institution: | 16468. Kazan (Volga Region) Federal University, ul. Kremlevskaya 18, Kazan, Tatarstan, 420008, Russia
26468. Institute of Biochemistry and Biophysics, Kazan Research Center, Russian Academy of Sciences, Kazan, Tatarstan, 420008, Russia
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| Abstract: | Effect of 2,4,6-trinitrotoluene (TNT) on callus cells of Tartar buckwheat (Fagopyrum tataricum (L.) Gaertn.) was accompanied by six-electron reduction of ortho- or para-nitro groups of the xenobiotic with the production of 2-amino-4,6-dinitrotoluene (2-ADNT) and 4-amino-2,6-dinitrotoluene (4-ADNT). It was discovered that the xenobiotic TNT impairs integrity of cell membrane, which apparently results from its one-electron reduction coupled with production of nitro radical-anion and superoxide anion. |
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