| 糖尿病大鼠膀胱和骶髓背根神经节中NGF 的表达与尿流动力学改变的研究 |
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| 引用本文： | 吴建红邵怡刘海涛陈辉容洪艳夏术阶. 糖尿病大鼠膀胱和骶髓背根神经节中NGF 的表达与尿流动力学改变的研究[J]. 现代生物医学进展, 2011, 11(5): 824-826 |
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| 作者姓名： | 吴建红邵怡刘海涛陈辉容洪艳夏术阶 |
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| 作者单位： | 上海交通大学附属第一人民医院泌尿外科,上海,200080 |
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| 基金项目： | 上海市科学技术委员会科研计划项目 |
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| 摘 要： | 目的:探讨糖尿病大鼠膀胱与骶髓背根神经节(DRG)中神经生长因子(NGF)的表达与尿流动力学改变。方法:建立糖尿病大鼠模型10只,对照组10只,应用酶联免疫吸附试验(ELISA)法,分别检测大鼠膀胱组织及骶髓DRG中NGF的变化情况,结合代谢笼及尿流动力学改变,探讨糖尿病膀胱病变的可能发病机制。结果:造模12周后,糖尿病大鼠膀胱容量较正常对照组明显增大(1.47±0.28vs0.71±0.12,p<0.05),残余尿量明显增多(0.52±0.18vs0.07±0.08,p<0.01),排尿效率明显下降,膀胱及骶髓DRG中NGF表达水平明显降低。结论:NGF在糖尿病大鼠膀胱和骶髓背根神经节中低表达,在糖尿病膀胱病变中发挥着重要作用。
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| 关 键 词： | 糖尿病膀胱 神经生长因子 尿流动力学 |
Expression of NGF in lumbar dorsal root ganglia and bladder of diabeticrats and urodynamic changes |
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| WU Jian-hong,SHAO Yi,LIU Hai-tao,CHEN Hui-rong,HONG Yan,XIA Shu-jie. Expression of NGF in lumbar dorsal root ganglia and bladder of diabeticrats and urodynamic changes[J]. Progress in Modern Biomedicine, 2011, 11(5): 824-826 |
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| Authors: | WU Jian-hong SHAO Yi LIU Hai-tao CHEN Hui-rong HONG Yan XIA Shu-jie |
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| Affiliation: | △ (First People’s Hospital Affiliated to Shanghai Jiao Tong University,Shanghai,200080,China) |
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| Abstract: | Objective:To evaluate the expression of nerve growth factor(NGF) in the bladder and sacral cord dorsal root ganglia(DRG) and the bladder function 8 weeks after diabetes induction and investigate the pathogenesis of diabetic cystopathy.Methods:Twenty Sprague-Dawley rats were divided into two groups:control(n=10),streptozotocin-induced diabetic group(n=10).Eight weeks later,the bladders and sacral cord DRG were dissected.We measured the expression of NGF in the bladders and sacral cord DRG using ELISA,evaluat... |
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| Keywords: | Diabetic cystopathy nerve growth factor(NGF) Urodynamics |
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