溶瘤腺病毒在肿瘤靶向治疗中的研究进展

溶瘤腺病毒是一组通过基因工程构建的腺病毒、能够选择性在肿瘤细胞中完成感染-复制周期,从而特异性地杀伤、溶解肿瘤而不伤及其他正常细胞、组织,其作用机制包括:通过基因的缺失突变、插入特异性启动子、以及通过病毒结构蛋白的修饰等方面,实现肿瘤靶向治疗作用。本文就相关研究及进展进行综述。

Progress of Target Therapy with Oncolytic Adenovirus for Cancer

Oncolytic adenovirus is a group of adenovirus,which constructed through genetic engineering. It can execute infection- replication cycle in tumor cells selectively, which specifically kill, dissolve tumors without harming normal cells, tissues. Its mechanisms include: the gene deletion mutants, inserted into specific promoter, and as well as through the modification of viral structural proteins, etc, to achieve targeted cancer therapy. In this review, oncolytic adenovirus for targeted cancer therapy research and progress are introduced.