Synthesis of purine bases having a di(hydroxymethyl)cyclopentenyl group by means of high-pressure reaction and their anti-HIV activity. |
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| Authors: | N Katagiri M Nomura H Sato C Tameda A Kurimoto S Arai A Toyota C Kaneko |
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| Institution: | Pharmaceutical Institute, Tohoku University, Sendai, Japan. |
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| Abstract: | The 1'- and 5'-hydroxymethyl derivatives of carbovir and related purine derivatives were synthesized from 5-hydroxymethylcyclopentadiene. The anti-HIV activity evaluation of these compounds has revealed that 9-(c-4,t-5-dihydroxymethylcyclopent-2-en-r-1-yl)-9H-adenine is a prospective chemotherapeutic agent against AIDS. |
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