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Unguisin C,a GABA-containing cyclic peptide from the fungus Emericella unguis |
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| Authors: | Malmstrøm Joan Ryager Anne Anthoni Uffe Nielsen Per Halfdan |
| Affiliation: | a Department of Structural Chemistry, Pharmaceuticals Development, Research and Development, Novo Nordisk A/S, Novo Nordisk Park, DK-2760, Maaloev, Denmark b Marine Chemistry Section, Department of Chemistry, University of Copenhagen, Universitetsparken 5, DK-2100, Copenhagen, Denmark |
| Abstract: | Besides the known unguisins A and B, a new cyclic heptapeptide, unguisin C, containing a GABA-derived moiety in the ring, was isolated from the fungus Emericella unguis. The structure was determined by 1D and 2D NMR techniques. Marfey's method was used to determine the absolute stereochemistry. Precursor-directed biosynthesis of the unguisins was performed by supplementation of the culture medium with amino acids (L-Ala, L-Ser, L-Phe and L-Leu). A related cyclic heptapeptide, unguisin D, was detected by HPLC and characterized by sequence analysis using LC-QITMS. |
| Keywords: | Emericella unguis Fungus Cyclic peptides GABA Unguisin C Unguisin D |
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