| 谷胱甘肽的抗线粒体脂质过氧化作用 |
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| 引用本文： | 高姝娟,刘锡锰,高贵,杨同书. 谷胱甘肽的抗线粒体脂质过氧化作用[J]. 中国生物化学与分子生物学报, 1997, 13(3): 287-291 |
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| 作者姓名： | 高姝娟 刘锡锰 高贵 杨同书 |
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| 作者单位： | 吉林大学酶工程国家重点实验室!长春，130023(高姝娟，高贵，杨同书)，吉林大学分子生物学系!长春，130023(刘锡锰) |
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| 基金项目： | 酶工程国家重点实验室开放基金!95010 |
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| 摘 要： | 谷胱甘肽是细胞内重要的抗氧化损伤物质之一．以NADH诱导的牛心肌线粒体脂质过氧化体系为模型，研究了谷胱甘肽的抗氧化作用．结果表明，一定浓度的谷胱甘肽能够部分抑制该体系中线粒体的脂质过氧化．保护组的丙二醛含量为损伤组72．5％；线粒体的膨胀度较损伤组降低；细胞色素C氧化酶及ATP酶活力分别较损伤组提高了1．5及2．2倍．
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| 关 键 词： | 线粒体 脂质过氧化 谷胱甘肽 |
| 收稿时间： | 1997-06-20 |
Antioxidative Effect of Glutathione on Lipid Peroxidation of Mitochondrion |
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| Gao Shu-Juan,Liu Xi-Meng,Gao Gui,Yang Tong-Shu. Antioxidative Effect of Glutathione on Lipid Peroxidation of Mitochondrion[J]. Chinese Journal of Biochemistry and Molecular Biology, 1997, 13(3): 287-291 |
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| Authors: | Gao Shu-Juan Liu Xi-Meng Gao Gui Yang Tong-Shu |
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| Affiliation: | (National Key Laboratory of Enzyme Engineering,Jilin Uniersity,Changchun 130023 |
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| Abstract: | Glutathione is believed to be very important in cellular defense against lipid peroxidation. Its effect on NADH-induced mitochondria lipid peroxidation system has been examined. The results showed that at certain concentration, GSH could partly prevent mitochondria from the damage of lipidperoxidation. Adding 10 μmol/L GSH to the injury system,the contents of malondialdehyde (MDA) was 72. 5% of that of the injury group;swelling of mitochondria decreased;membrane fluidity increased;activities of cytochrome c oxidase and ATPase of mitochndria were 1.5-fold and 2. 2-fold respectively of that in the injury group. |
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| Keywords: | Mitochondrion Lipid peroxidation Glutathione |
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