Formation of rosettes by nonspecific lymphoid cells which have adhered to antigen-antibody complexes |
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| Authors: | I Siegel |
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| Institution: | Allergy-Clinical Immunology and Infectious Disease Division Medical Service, R. A. Cooke Institute of Allergy, The Roosevelt Hospital, New York, N. Y. 10019 U.S.A. |
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| Abstract: | Rat lymph node-sheep red cell rosettes have been formed through the adherence of nonspecific small lymphocytes and larger cell types to antibody-sheep red cell complexes. Enough antibody to form a significant number of rosettes has been synthesized in cultures, containing draining lymph node cells of immunized rats, within 1 hr of incubation at 37 °C, or during overnight storage at 4 °C. This suggests that conditions which differentiate between specific and nonspecific rosette-forming cells are essential when immunocyto-adherence phenomena are utilized for the study of the specificity of the immune response. |
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