Ensuring safety of DNA vaccines |
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Authors: | Email author" target="_blank">Jacob?GlentingEmail author Stephen?Wessels |
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Institution: | 1.Bioneer A/S,H?rsholm,Denmark;2.Danish Toxicology Centre,H?rsholm,Denmark |
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Abstract: | In 1990 a new approach for vaccination was invented involving injection of plasmid DNA in vivo, which elicits an immune response to the encoded protein. DNA vaccination can overcome most disadvantages of conventional
vaccine strategies and has potential for vaccines of the future. However, today 15 years on, a commercial product still has
not reached the market. One possible explanation could be the technique's failure to induce an efficient immune response in
humans, but safety may also be a fundamental issue. This review focuses on the safety of the genetic elements of DNA vaccines
and on the safety of the microbial host for the production of plasmid DNA. We also propose candidates for the vaccine's genetic
elements and for its microbial production host that can heighten the vaccine's safety and facilitate its entry to the market. |
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