Heterologous expression in <Emphasis Type="Italic">Tritrichomonas foetus</Emphasis> of functional <Emphasis Type="Italic">Trichomonas vaginalis</Emphasis> AP65 adhesin |
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Authors: | Ashwini?S?Kucknoor Vasanthakrishna?Mundodi Email author" target="_blank">JF?AldereteEmail author |
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Institution: | (1) Department of Microbiology, University of Texas Health Science Center at San Antonio, 7703, Floyd Curl Dr. San Antonio, TX 78229-3900, USA |
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Abstract: | Background Trichomonosis, caused by Trichomonas vaginalis, is the number one, nonviral sexually transmitted infection that has adverse consequences for the health of women and children.
The interaction of T. vaginalis with vaginal epithelial cells (VECs), a step preparatory to infection, is mediated in part by the prominent surface protein
AP65. The bovine trichomonad, Tritrichomonas foetus, adheres poorly to human VECs. Thus, we established a transfection system for heterologous expression of the T. vaginalis AP65 in T. foetus, as an alternative approach to confirm adhesin function for this virulence factor. |
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