Chronic development of collagen-induced arthritis is associated with arthritogenic antibodies against specific epitopes on type II collagen |
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Authors: | Estelle?Bajtner Kutty?S?Nandakumar ?ke?Engstr?m Email author" target="_blank">Rikard?HolmdahlEmail author |
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Institution: | (1) Medical Inflammation Research, Lund University, Lund, Sweden;(2) Uppsala Biomedical Center, IMBIM, Uppsala, Sweden |
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Abstract: | Antibodies against type II collagen (CII) are important in the development of collagen-induced arthritis (CIA) and possibly
also in rheumatoid arthritis. We have determined the fine specificity and arthritogenicity of the antibody response to CII
in chronic relapsing variants of CIA. Immunization with rat CII in B10.Q or B10.Q(BALB/c×B10.Q)F2 mice induces a chronic relapsing CIA. The antibody response to CII was determined by using triple-helical peptides of the
major B cell epitopes. Each individual mouse had a unique epitope-specific response and this epitope predominance shifted
distinctly during the course of the disease. In the B10.Q mice the antibodies specific for C1 and U1, and in the B10.Q(BALB/c×B10.Q)F2 mice the antibodies specific for C1, U1 and J1, correlated with the development of chronic arthritis. Injection of monoclonal
antibodies against these epitopes induced relapses in chronic arthritic mice. The development of chronic relapsing arthritis,
initially induced by CII immunization, is associated with an arthritogenic antibody response to certain CII epitopes. |
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