Capillaria hepatica infection of Mastomys natalensis: on the development, egg production and host reaction (author's transl)]

Studies on the development and egg production of Capillaria hepatica and on the macroscopically visible alterations of the liver and spleen of the host were carried out in experimentally infected Mastomys natalensis. Following the oral administration of infective eggs the first stage larvae hatched in the caecum of fasting and fed animals after about 8 and 15 hours respectively. The prepatency could be found with 20 days. The dynamics and duration of egg production of the parasite proved to be dependent on the infective dose. After the first week of patency increasing numbers of eggs/liver were found with increasing doses of infection up to 800 eggs per animal. This relation could not be observed 76 days post infection. After infections with 50, 300 und 800 eggs per animal maximum egg production was found between 60 and 72, 36 and 48 and about 30 days p.i., respectively. The egg production of the parasites correspondently continued for more than 85 days after infection or had ceased 72 or 48 days p.i. Intraperitoneal administration of infective eggs revealed a lower infection rate, evaluated by the number of eggs per liver, than oral infection.