Inhibition of taurocholate efflux from rat hepatic canalicular membrane vesicles by glutathione disulfide |
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| Authors: | J C Griffiths H Sies P J Meier T P Akerboom |
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| Affiliation: | 1. Institut für Physiologische Chemie I, Universität Düsseldorf, Moorenstrasse 5, D-4000 Düsseldorf, FRG;2. Department für Innere Medizin, Medizinische Klinik, Universitätsspital Zürich, CH-8091 Zürich, Switzerland |
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| Abstract: | In right-side out rat hepatic canalicular membrane vesicles glutathione disulfide (GSSG) inhibited the efflux of taurocholate approx. 70% in the presence or approx. 55% in the absence of a valinomycin-mediated K+ diffusion potential; maximal inhibition occurred at 5 mM GSSG. The inhibition by GSSG was abolished by dithioerythritol. Neither dithioerythritol alone nor GSH inhibited taurocholate efflux. S-(2,4-Dinitrophenyl)glutathione and N-ethylmaleimide showed intermediate inhibitory effects. |
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