Tandem duplication chromosome 21 in the offspring of a ring chromosome 21 carrier |
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Authors: | K Miller A Reimer B Schulze |
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Institution: | Abteilung Humangenetik, Medizinischen Hochschule Hannover, FRG. |
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Abstract: | A direct tandem duplication chromosome 21 was found in a boy with Down's syndrome. The proband's mother and grandmother both carried a ring chromosome 21. The observed duplication chromosome in the child may be explained either by recombination between the maternal ring and the mother's normal chromosome 21 or by break of a double-sized ring chromosome 21. |
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