穿膜肽的内化机制及其应用

穿膜肽是一类具有特殊穿膜功能的多肽分子，能携带其它分子甚至超分子颗粒穿膜进入细胞内部．早期研究认为，其进胞是一种无需受体、也不存在饱和状态的非经典胞吞行为．近年研究表明，其穿膜机制可能与其含有的氨基酸种类有很大关系．现在，穿膜肽的穿膜过程称为巨型胞饮行为，它与传统的胞吞形式很相似．当然，还可能存在着其它的进胞方式而没有被证明或发现．关于穿膜肽的应用也是人们最感兴趣的，在很多领域的研究都在进行并不断取得进展．不论是生物界还是医学界，穿膜肽都被认为将是一类非常有发展潜力的多肽分子．

Mechanism of Cell-penetrating Peptides-mediated Internalization and Its Application

Cell-penetrating peptides(CPPs) are short peptides of less than 30 amino acids that are able to penetrate cell membranes and translocate different cargoes into cells. Cargoes that are successfully internalized by CPPs range from small molecules to proteins and supramolecular particles. In recent years, scientists have carried out studies about theirs structures, properties, cytotoxicities and mechanisms penetrating membrances. CPPs are novel vehicles for the translocation of cargo into cells, whose properties make them potential drug delivery agents, of interest for future use.