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Synthesis of pyrrolo[2,3-d]pyrimidine nucleoside derivatives as potential anti-HCV agents |
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| Authors: | Varaprasad Chamakura V N S Ramasamy Kanda S Girardet Jean-Luc Gunic Esmir Lai Vicky Zhong Weidong An Haoyun Hong Zhi |
| Affiliation: | Drug Discovery, Valeant Pharmaceuticals Research and Development, 3300 Hyland Avenue, Costa Mesa, CA 92626, USA |
| Abstract: | Several Toyocamycin (4) analogues were examined for their ability to inhibit HCV RNA in a replicon assay. Among the compounds examined 4-methylthio (18) and 5-carboxamide oxime derivatives (23 and 27) of Toyocamycin were found to have good activity and selectivity. |
| Keywords: | HCV NS5B inhibitors Toyocamycin Pyrrolo[2,3-d]pyrimidine nucleosides |
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