CLIPs and CLASPs and cellular dynamics |
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| Authors: | Galjart Niels |
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| Institution: | Department of Cell Biology and Genetics, Erasmus Medical Centre, P.O. Box 1738, 3000 DR, Rotterdam, The Netherlands. n.galjart@erasmusmc.nl |
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| Abstract: | The dynamic properties of microtubules are regulated by plus-end tracking proteins (+TIPs), which associate with the distal ends of microtubules. Among the +TIPs are cytoplasmic linker proteins (CLIPs), which promote microtubule growth and regulate dynein-dynactin localization, and CLIP-associating proteins (CLASPs), which stabilize specific subsets of microtubules on reception of signalling cues. CLIPs and CLASPs interact and cooperate to direct the microtubule network, thereby regulating cellular asymmetry. |
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